The human adenovirus type 5 L 4 promoter is negatively regulated by TFII - I and by L 4 - 33 K
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چکیده
The human adenovirus type 5 L4 promoter is negatively regulated by TFII-I and by L4-33K 1 Jordan Wright†, Zeenah Atwan, Susan J. Morris‡ and Keith N. Leppard# 2 School of Life Sciences, University of Warwick, Coventry CV4 7AL, U.K. 3 4 5 # Address correspondence to Keith Leppard, [email protected] 6 † Present address: Oxford Biomedica Plc, Medawar Building, Oxford Science Park, Oxford, OX4 7 4GA, U.K. 8 ‡ Present address: Jenner Ins tute, ORCRB, University of Oxford, Oxford OX3 7DQ, U.K. 9 10 Running Title: Characterization of the adenovirus L4P promoter 11 12 Words in abstract: 196 13 Words in text: 6722 14 15 JVI Accepted Manuscript Posted Online 29 April 2015 J. Virol. doi:10.1128/JVI.00683-15 Copyright © 2015, American Society for Microbiology. All Rights Reserved.
منابع مشابه
The Human Adenovirus Type 5 L4 Promoter Is Negatively Regulated by TFII-I and L4-33K
UNLABELLED The late phase of adenovirus gene expression is controlled by proteins made in the intermediate phase, including L4 proteins of 22,000- and 33,000-Da apparent molecular mass (L4-22K and -33K proteins) that are expressed initially from the L4 promoter (L4P). The L4P is activated by a combination of viral proteins and cellular p53 and is ultimately inhibited again by its own products. ...
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متن کاملJAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase.
TFII-I is a transcription factor that shuttles between the cytoplasm and nucleus and is regulated by serine and tyrosine phosphorylation. Tyrosine phosphorylation of TFII-I can be regulated in a signal-dependent manner in various cell types. In B lymphocytes, Bruton's tyrosine kinase has been identified as a TFII-I tyrosine kinase. Here we report that JAK2 can phosphorylate and regulate TFII-I ...
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متن کاملPolymorphism in the interleukin-10 promoter affects both provirus load and the risk of human t lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis
To investigate candidate genes that influence the risk of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), we analyzed 6 single nucleotide polymorphisms (SNP) in the interleukin-10 (IL-10) promoter region. METHODS: 280 cases of HAM/TSP patients and 255 HTLV-I seropositive asymptomatic carriers (HCs) from Kagoshima, Japan were studied. All subjects gave written informed conse...
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تاریخ انتشار 2015